Clinical Significance of Arg306 Mutations of Factor V Gene

Abstract

To the Editor: Human coagulation factor V is a cofactor involved in the conversion of prothrombin to thrombin. Activated factor V is normally inactivated by activated protein C (APC) in the process of hemostasis.[1][1]Activated factor V is initially cleaved at Arg506 and then at Arg306 and Arg679.