Unified Total Syntheses of the Inositol Polyphosphates: <scp>d</scp>-I-3,5,6P₃, <scp>d</scp>-I-3,4,5P₃, <scp>d</scp>-I-3,4,6P₃, and <scp>d</scp>-I-3,4,5,6P₄ via Catalytic Enantioselective and Site-Selective Phosphorylation

Abstract

Synthetic routes to various inositol polyphosphates have been discovered utilizing catalytic enantioselective and site-selective phosphorylation reactions. The syntheses described herein exploit a common intermediate to gain efficient access to eight unique inositol polyphosphates.