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A NEW SCANNING ISOTOPE, MERCURY-197. A PRELIMINARY REPORT.
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1963
Year
EngineeringRadiation EffectRadiation ExposurePathologyGliomaMercury BiogeochemistryRadiopharmaceutical TherapyToxicologyNew Scanning IsotopeRadiation OncologyNuclear MedicineCancer ResearchRadiologyIsotope AnalysisRadiation TherapyRadiation EffectsBrain Tumor TissueMercury ChemistryIsotope GeochemistryRadiation DoseMedicineHuman Organ Localization
The human organ localization and excretion of intravenous Hg/sup 197/ chloride was investigated. The radiation exposure to the human kidney was reduced from 5 rads, utilizing Hg/sup 209/ Neohydrin to.6 rad with Hg/sup 197/ per 100-microcurie dose. Diagnostic photoscans were produced of the kidneys, liver, and spleen with far less radiation to the individual organ than with the previously recommended scanning isotope. Twenty to twenty-five times more Hg/sup 197/ localized in brain tumor tissue than normal, but slow clearance of blood makes brain scanning impractical with unbound Hg/sup 197/. Chloromerodrin tagged with Hg/dup 197/ will further reduce radiation dose to the kidney of the patient by a factor of 200. (P.C.H.)