Journal of Clinical Laboratory Analysis · 2016 · 37 citations · 15 references
MedicineEndocrinologyMolecular MedicineAutoimmunityDiabetologyGene ExpressionDiabetes MellitusInsulin ResistanceMicrorna BiologyPancreatic DiseasesPancreatic EndocrinologyPancreatic HormonesBeta Cell BiologyBeta-cell DysfunctionCirculating MicrornasDiabetes Mellitus PathophysiologyIslet Cell DysfunctionPancreatic Beta-cell FunctionPancreatic Islet CellsType 1 Diabetes Pathophysiology
BACKGROUND: miRNA-181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta-cells dysfunction. METHODS: miRNA-181a expression was evaluated by real-time PCR in serum of 40 type 1 diabetic children and adolescents and 40 age- and gender-matched healthy controls. RESULTS: miRNA-181a expression was significantly higher in diabetic children and adolescents and it was negatively correlated to fasting C-peptide and SMAD7 levels. CONCLUSION: miRNA-181a appears to play a potential role in pancreatic beta-cells dysfunction via SMAD7.
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