Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats

Abstract

The present study indicates that rapamycin cannot prevent epilepsy in the electrical stimulation post-SE rat model but has seizure-suppressing properties as long as rapamycin blood levels are sufficiently high. Oral curcumin treatment had no effect on chronic seizures, possibly because it did not reach the brain at adequate levels.