Hodgkin's Disease of the Lung ^1, ²

Abstract

The records of 29 patients with Hodgkin's disease involving the lung were reviewed to determine the pathologic features of Hodgkin's disease with lung involvement, the diagnostic and prognostic significance of the radiographic manifestations of lung involvement, and the clinical course of the disease after lung involvement was recognized. Twenty-six of the 29 patients had nodular sclerosing Hodgkin's disease, a frequency far in excess of the relative frequency of this particular cell type in the population from which the patients were selected. In all patients who had not previously received anterior mediastinal radiation or systemic chemotherapy, hilar adenopathy was present when lung involvement was recognized. The development of diffuse involvement of both lungs during the course of follow-up was a grave prognostic sign. Mean survival after recognition of lung involvement was 23 months.