PubMed · 1986 · 37 citations · 0 references
MedicineOncologySurgeryChemotherapyGastrointestinal OncologyOncology PharmacotherapyEsophageal CancerEsophageal DiseasesEsophageal SurgeryGastrointestinal Cancer PharmacotherapyGastrointestinal Cancer SurgerySquamous Cell CarcinomaContinuous Infusion DosingContinuous Infusion PharmacologyEsophageal Cancer PharmacotherapyPhase Ii InvestigationStudy Phase
Forty patients with advanced squamous cell carcinoma of the esophagus were treated with a combination of cisplatin, 5-FU (by continuous 5-day infusion), and allopurinol; 37 are evaluable for response. Thirteen remissions (35%) were obtained, including three complete and ten partial, with a median duration of 9 months. After chemotherapy, seven responding patients underwent a surgical procedure, which was radical in four. The most frequent side effects were nausea and vomiting. This regimen is effective and can be included in a multimodality approach.