Protection of platelets during long-term extracorporeal membrane oxygenation in sheep with a single dose of a disintegrin. - Concepedia

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Protection of platelets during long-term extracorporeal membrane oxygenation in sheep with a single dose of a disintegrin.

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References

1992

Year

Osamu Shigeta, Stephen W. Downing, Weiqi Lu, S Niewiarowski, L H Edmunds

Abstract

A single dose of bitistatin given before blood contact with the ECMO circuit briefly inhibits platelet adhesion and aggregation but thereafter preserves platelet numbers and function and suppresses alpha-granule release for 12-16 hours of ECMO.