Publication | Open Access
α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA<sub>B</sub>receptors
94
Citations
49
References
2016
Year
Vc1.1-mediated activation of GABA<sub>B</sub>R is a novel mechanism for reducing the excitability of human DRG neurons. Vc1.1-induced activation of GABA<sub>B</sub>R on the peripheral endings of colonic afferents reduces nociceptive signalling. The enhanced antinociceptive actions of Vc1.1 during CVH suggest it is a novel candidate for the treatment for CVP.
| Year | Citations | |
|---|---|---|
Page 1
Page 1