Metabotropic Regulation of RhoA/Rho-Associated Kinase by L-type Ca ²⁺ Channels

Abstract

These findings reveal that calcium channel-induced Ca(2+) release has a major role in tonic vascular smooth muscle contractility because it links membrane depolarization and Ca(2+) channel activation with metabotropic Ca(2+) release and sensitization (RhoA/ROCK stimulation).