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Antitumor Immunity. II. Viability, Tumorigenicity, and Immunogenicity of Neuraminidase-Treated Tumor Cells: Effective Immunization of Animals With a Tumor Vaccine 2
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1976
Year
Veterinary VaccineImmunologyPathologyAntitumor ImmunityTumor VaccineImmunotherapyTumor ImmunologyTumor ImmunityCancer VaccinesTumor Vaccine 2Cell TransplantationRadiation OncologyMucosal VaccinationVaccine DevelopmentTumor DevelopmentTherapeutic VaccineEffective ImmunizationVaccinationVaccine DesignMedicineVaccine ResearchReduced Transplantability
A dimethylbenzdithionaphthene (DBDN)-induced fibrosarcoma showed reduced transplantability if previously treated with Vibrio cholerae neuraminidase (VCN). However, the reduced transplantability of VCN-treated tumor cells was not associated with any loss of their viability or tumorigenic capability, but appeared to be due to their increase in immunogenicity. High doses of VCN-treated tumor cells could grow even in normal individuals. Lower doses, which did not induce tumor development in normal individuals, did so if injected into immunosuppressed animals. Although X-irradiation of VCN-treated tumor cells reduced their tumorigenic potential, it did not impair their increased immunogenic properties. Thus a suitable method for the preparation of a "tumor vaccine" was provided. The immunization of animals with the vaccine and a working hypothesis regarding its mechanism of action were described.