The Colorado-Pittsburgh Cadaveric Renal Transplantation Study with Cyclosporine

Abstract

O UR EXPERIENCE with cyclosporine for cadaveric renal transplantation began in late 1979.An article by CaIne et al. l had just been published that gave critics of our trial a lot of ammunition.Although the pathfinding report by Caine and his associates contained the good news that rejection of some cadaveric kidneys had been avoided with no drug other than cyclosporine, the bad news was that there had been a high patient mortality in these Cambridge trials, that none of the kidneys was providing normal function, and that nearly 10% of the recipients had developed Iymphomas.l