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Bone Marrow Transplantation From Genetically HLA-Nonidentical Donors in Children With Fatal Inherited Disorders Excluding Severe Combined Immunodeficiencies: Use of Two Monoclonal Antibodies to Prevent Graft Rejection

DOI

47

Citations

0

References

1996

Year

Nada Jabado, F Le Deist, A J Cant, E R De Graeff-Meeders, Anders Fasth, Gareth J. Morgan, Ashok Vellodi, G Hale, Carolin Thomas, Marina Cavazzana,
PEDIATRICS

Abstract

The overall engraftment rate and overall survival rate with engraftment in patients treated with anti-LFA-1 and anti-CD2 were similar to those in patients treated with anti-LFA-1 antibody alone. However, although the number of patients is too small to draw definitive conclusions, results from the combined use of the two MoAbs indicates a trend toward better engraftment and survival after infusion of E rosette-depleted marrow. Further improvement in survival would demand additional strategies to hasten immunologic recovery.