Journal of Bone and Joint Surgery · 1970 · 47 citations · 0 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryAntimicrobial PharmacotherapyMusculoskeletal InfectionOrthopedicsBacterial InfectionsBone InfectionsJoint InfectionsOrthopedic InfectionOsteomyelitisSeptic ArthritisAntibiotic Penetration Into BoneAntibiotic Penetration Into TissueBone Infection TherapyCollateral Circulation AugmentationOsteomyelitis Antibiotic ManagementStaphylococcal Infection TherapyStaphylococcus Aureus Musculoskeletal InfectionVenous Return
The development of collateral circulation through the venous channels of bone was demonstrated in the hind legs of rabbits by infusion under pressure while the proximal venous outflow was obstructed by tourniquet. Experimental staphylococcal arthritis and osteomyelitis were treated by antibiotics administered by perfusion, with a lower mortality rate and much greater chance of sterilizing the local lesion, when compared with systemic treatment. It is suggested that this method may be of value in the treatment of human infectious.