Silver-Catalyzed Cascade Radical Cyclization: A Direct Approach to 3,4-Disubstituted Dihydroquinolin-2(1<i>H</i>)-ones through Activation of the P–H Bond and Functionalization of the C(sp²)–H Bond

Abstract

A silver-catalyzed cascade cyclization of cinnamamides with diphenylphosphine oxide was developed, in which activation of the P-H bond and functionalization of the C(sp(2))-H bond occurred. A direct method for the synthesis of 3,4-disubstituted dihydroquinolin-2(1H)-ones was developed.