Concepedia

Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies

Tatyana Grayfer, Philippe Grellier, Elisabeth Mouray, Robert H. Dodd, Joëlle Dubois, Kevin Cariou

Organic Letters · 2016 · 17 citations · 22 references

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Abstract

The first total syntheses of mallotojaponin B and C as well as several analogues have been achieved. Biological evaluation of the synthesized compounds against Plasmodium falciparum and Trypanosoma brucei have also been carried out.

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Na<sup>+</sup>-Glucose Cotransporter (SGLT) Inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4‘-Dehydroxyphlorizin Derivatives Substituted on the B Ring

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