Docking Studies and Synthesis of Novel Flavones Screened for Biological Activities like Anticancer and Antioxidant Activity

Abstract

Flavones are the derivatives of flavonoids, possessing the wider range of biological actions. A novel series of flavonoid Derivatives with the help of substituted benzaldehyde were synthesized and screened for biological activities like anticancer and antioxidant activity. All synthesized derivatives were screened for in-vitro cytotoxicity by Brine shrimp lethality assay in which 1-(2, 4-dihydroxyphenyl)-3-(4-(dimethyl amino) phenyl) prop-2ene-1one. (MCR-001) and 2-(4-(Di-methylamino) phenyl)-7-hydroxy-4-H-chromen-4-one. (MCR-002), 2-hydroxy-2-(4-(methyl (4-nitrostyryl) amino) phenyl)-4-oxochroman-7-yl benzoate. (MCR-004) and 2-(4dimethyl amino) phenyl)-4-oxo-4H-chromen-7-yl benzoate. (MCR-005) showed highest anticancer activity as compared to 5-fluorouracil due to presence of hydroxy group. Among synthesized compounds, 4-nitro flavonoids compound derivatives were screened for antioxidant activity by using DPPH Scavenging Method. 2(4-dimethyl amino) phenyl)-2-hydroxy 4-oxochroman-6-yl benzoate (MCR-005) showed highest antioxidant activity as compared to ascorbic acid. This work has revealed the scope and potential of flavonoids for future exploration to synthesize substituted flavonoids and chalcone derivatives by the use of different substituted benzaldehyde.