Concepedia

Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-bromopyridines via phosphine-free palladium-catalyzed C–H bond arylations: the importance of the C6 substituent

Wided Hagui, Néji Besbes, Ezzeddine Srasra, Jean‐François Soulé, Henri Doucet

RSC Advances · 2016 · 22 citations · 86 references

DOI

Concepts

Abstract

A Pd(OAc)<sub>2</sub>catalyst promotes the arylation of heteroarenes with 6-substituted 2-bromopyridines,<italic>via</italic>C–H bond activation, providing straightforward access to 2-(hetero)arylpyridines.

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