Sodium Thiosulfate Treatment of Soft -Tissue Calcifications in Patients with End-Stage Renal Disease

Abstract

Five patients on maintenance hemo dialysis for more than five years, who had tumoral calcifications, were treated by sodium thiosulfate for three to IS months. Four patients with periarticular and soft-tissue calcifications achieved regression of varying degrees and the motion of the adjacent joints was considerably improved. The fifth patient had calcification of penis; sodium thiosulfate produced early relief of symptoms and later complete disappearance of the calcification.