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Intratumorally Injected <sup>177</sup>Lu-Labeled Gold Nanoparticles: Gold Nanoseed Brachytherapy with Application for Neoadjuvant Treatment of Locally Advanced Breast Cancer

Simmyung Yook, Zhongli Cai, Yijie Lu, Mitchell A. Winnik, Jean‐Philippe Pignol, Raymond M. Reilly

Journal of Nuclear Medicine · 2016 · 111 citations · 13 references

DOIFull text

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Abstract

Gold nanoseeds injected intratumorally were highly effective for inhibiting the growth of breast cancer tumors in CD-1 athymic mice and caused no normal organ toxicity. These results are promising for their application for neoadjuvant brachytherapy of LABC. Because EGFR targeting was not required, the approach is broadly applicable to LABC with different phenotypes.

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