Concepedia

A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial

Richard A. Brigandi, Brendan M. Johnson, Coreen Oei, Mark Westerman, Gordana Olbina, Janak de Zoysa, Simon D. Roger, Manisha Sahay, Nicholas Cross, Lawrence P. McMahon,

American Journal of Kidney Diseases · 2016 · 159 citations · 12 references

DOIFull text

Open access

Concepts

References

12

Regulation of hypoxia-inducible factor 1α is mediated by an O <sub>2</sub> -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

, , +15

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Susana Alicia Salceda, J. Jaime · Journal of Biological Chemistry · 1997 · 1.7K citations · Full text

, , +15

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Maria Mastrogiannaki, Pavle Matak, Brian Keith et al. · Journal of Clinical Investigation · 2009 · 494 citations · Full text

, , +17

Hepcidin—A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease

Joshua J. Zaritsky, Brian Young, He-Jing Wang et al. · Clinical Journal of the American Society of Nephrology · 2009 · 350 citations · Full text

, , +15

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

Wanja M. Bernhardt, Michael S. Wiesener, P. Scigalla et al. · Journal of the American Society of Nephrology · 2010 · 342 citations · Full text

, , +13