Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients.

Abstract

The recommended phase II dose of 9-AC given by 72-hour infusion every 2 weeks is 35 microg/m2/h without G-CSF or 47 microg/m2/h with G-CSF support. Dose escalation in individual patients may be possible according to their tolerance.