Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma

Abstract

Inhaled allergen increases DCs in bone marrow and trafficking of DCs into the airway, which is associated with the development airway inflammation in subjects with allergic asthma. Inhaled allergen challenge also increases expression of TSLP, but not IL-33, receptors on bone marrow DCs.