Clinical Chemistry · 1976 · 80 citations · 0 references
PharmacyPharmacokineticsPharmacologyBioavailabilityDrug ClearancePharmacokinetic ModelingArea Under The CurveClearance EstimationCompartmental Pharmacokinetic ModelsDrug Concentration InterpretationDrug DispositionPharmacokinetic SamplingDrug Clearance EstimationFree Drug Concentration MeasurementPharmacokinetic Parameter AnalysisPharmacokinetic ParametersPharmacokinetic PrinciplesPharmacokinetic Two-compartment ModelsProtein-drug BindingTherapeutic Drug Monitoring Models
We review some pharmacokinetic principles that can facilitate interpretation of data obtained during therapeutic drug monitoring: the one- and two-compartment models, volume of drug distribution, drug clearance, organ clearance, bioavailability, first-pass effect, chronic or repetitive dosing, and use of urine and saliva to measure drug clearance and drug binding to plasma proteins, respectively. We also describe use of saliva to estimate rapidly, conveniently, and noninvasively the concentration of the free, pharmacologically active form of the drug as well as the fraction of drug bound to plasma protein.