Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod γ-aminobutyric acid- and l-glutamate-gated chloride channels and insecticidal/acaricidal activity

Christian Wolf, Sandra Noack, Heike Williams et al. · Insect Biochemistry and Molecular Biology · 2013 · 318 citations · Full text

Medicine, Entomology, Pharmacology +17

The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels

Yoshihisa Ozoe, Miho Asahi, Fumiyo Ozoe et al. · Biochemical and Biophysical Research Communications · 2009 · 284 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

Wesley L. Shoop, Eric J. Hartline, Brandon R. Gould et al. · Veterinary Parasitology · 2014 · 191 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Statistical Analysis of the Effects of Common Chemical Substituents on Ligand Potency

Philip J. Hajduk, Daryl R. Sauer · Journal of Medicinal Chemistry · 2008 · 97 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

George P. Lahm, Daniel Cordova, James D. Barry et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 79 citations

Medicine, Entomology, Pharmacology +13