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Oxygen Sensing and the Electrophysiology of Arterial Chemoreceptor Cells
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1993
Year
Glomus CellsCellular PhysiologySocial SciencesOxidative StressHyperpolarization (Biology)Oxygen SensingRespiratory CenterBiophysicsRespiratory NeurobiologyVascular BiologyCarotid BodiesNervous SystemPharmacologySignal TransductionNeurophysiologyPhysiologyTissue OxygenationElectrophysiologyMedicine
The carotid bodies sense reductions in arterial oxygen tension (PO2) and stimulate the respiratory center to induce hyperventilation. Lowering PO2, detected by O2-sensitive K+ channels, evokes a selective inhibition of the K+ current of glomus cells, with an increase of cellular excitability and cytosolic Ca2+.