Uptake of Lanthanum by Smooth Muscle

Abstract

140 La 3+ was taken up and tightly bound by rat myometrium. Its calculated volume of distribution was much greater than tissue water, and it was associated after cell fractionation with cellular particulates. The highest amounts were found in mitochondria. These results invalidate assumptions that La 3+ is confined to the extracellular space and limited in its action to the cell surface.