Dementia and Geriatric Cognitive Disorders Extra · 2015 · 26 citations · 38 references
MedicineNeurologyObstetricsDementiaGeriatricsHigh-risk PregnancyAlzheimer DiseaseDementia EpidemiologyDementia Risk FactorsHypertensive DisordersPregnancyPregnancy-induced HypertensionAlzheimer Disease EpidemiologyCase-control Study DesignCognitive ComplaintsHypertensive Disorder ComorbidityHypertensive Disorder HistoryPregnancy-related HypertensionWhite Matter AbnormalitiesWhite Matter Lesions
BACKGROUND: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD). AIM: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD. METHODS: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed. RESULTS: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD. CONCLUSION: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.
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W. T. Longstreth, Teri A. Manolio, Alice M. Arnold et al. · Stroke · 1996 · 1.5K citations
Corine M. Koopmans, Denise Bijlenga, Henk Groen et al. · The Lancet · 2009 · 790 citations
Medicine, Gynecology, Obstetrics +12