Gastric hemorrhage induced by nonnarcotic analgetic agents in dogs

Abstract

The effect of various nonnarcotic analgetic agents in producing gastric hemorrhage has been investigated in Pavlov‐pouch dogs. Of the compounds tested, only aspirin in suspension at pH 3.0 produced extensive bleeding. The same drug in solution, as well as salicylic acid, salicylamide, methylsalicylate, and acetaminophen, produced no significant effect. Intravenous aspirin in high doses failed to cause gastric effects.