Publication | Closed Access
Hepatoma and Renal Tubule Adenoma in Rats Fed Aflatoxin and Cyclopropenoid Fatty Acids<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>
15
Citations
0
References
1969
Year
Renal PathologyCrude Aflatoxin PreparationRenal InflammationPathologyMycotoxinsFatty Liver DiseaseToxicological MechanismOxidative StressGrowth RateMycotoxin FormationToxicologyHepatotoxicityRenal Tubule AdenomaHealth SciencesBiochemistryLiver PhysiologyHistopathologySterculia Foetida OilRenal PathophysiologyMetabolomicsCyclopropenoid Fatty AcidsPharmacologyDrug-induced Liver InjuryRats Fed AflatoxinHepatologyPhysiologyLiver DiseaseMetabolismMedicineKidney Research
A crude aflatoxin preparation containing 50% aflatoxin B1 and 42% aflatoxin G1 was fed to weanling male rats of the Long-Evans strain to supply 18.4, 184, 552, and 736 parts per billion total toxin. Duplicate groups fed the 3 lower levels of aflatoxin also received Sterculia foetida oil that supplied 220 parts per million cyclopropenoid fatty acids (CPFA). During the 18-month experiment, of the rats fed aflatoxin, 34% developed renal tubule adenomas, 10% hepatocellular carcinomas, and 31% hyperplastic liver nodules. S. foetida oil caused a slight but significant decrease in growth rate, and a slightly higher incidence of total tumors (70% as compared to 59%) was found in the animals fed CPFA together with aflatoxins.