Gold(I)‐Catalyzed Synthesis of Tetrahydrocarbazoles <i>via</i> Cascade [3,3]‐Propargylic Rearrangement/[4+2] Cycloaddition of Vinylindoles and Propargylic Esters

Abstract

Abstract A gold(I)‐catalyzed cascade [3,3]‐propargylic rearrangement and [4+2] cycloaddition reaction of 2‐vinylindoles with propargylic esters is reported. The reaction leads to the synthesis of highly substituted tetrahydrocarbazole derivatives in high yields and diasteroselectivities. Furthermore, a preliminary screening for an asymmetric version of this reaction is described. magnified image