Concepedia

Publication | Open Access

A new HIF‐1α/RANTES‐driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

DOIFull Paper Access

44

Citations

25

References

2016

Year

Mei Yee Koh, Mihai Gagea, Timothy Sargis, Robert Lemos, Geoffrey Grandjean, Adriana Charbono, Vasileios Bekiaris, John R. Šedý, Galina M. Kiriakova, Xiuping Liu,
Hepatology

Abstract

This work establishes a new tumor-suppressor role for HAF in immune cell function by preventing inappropriate HIF-1 activation in male mice and identifies RANTES as a novel therapeutic target for NASH and NASH-driven HCC.

References

YearCitations

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