Studies in detoxication. 47. The formation of ester glucuronides of aliphatic acids during the metabolism of 2-ethylbutanol and 2-ethylhexanol

Abstract

The octyl alcohol, DL-2-ethyl-fl-hexanol, is used industrially as a solvent and, in the form of the ester, di-2-ethylhexyl phthalate, as a plasticizer. According to After feeding the DL-alcohol to rabbits, Akiya & Yama- kawa (1950) isolated o-ethylhexanoic acid (a- ethylcaproic) from the urine, showing a slight positive rotation. They also found a dibasic acid with a slight positive rotation. No reports of the formation ofglucuronide from the alcohol have been made. The toxicity of 2-ethylhexanol is comparable with that of isooctyl alcohol, the anaesthetic dose of both alcohols being near the lethal dose in rats