Serum Voriconazole Level Variability in Patients with Hematological Malignancies Receiving Voriconazole Therapy

Abstract

In ill patients with acute leukemia and related disorders undergoing treatment with oral voriconazole, there is a poor correlation between the voriconazole dose and plasma concentrations, and many patients achieve levels that are considered to be subtherapeutic. The findings support the routine use of therapeutic drug monitoring in these patients.