Association of <i>MTHFR</i> C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype

Abstract

MTHFR C677T was associated with magnetic resonance imaging-confirmed lacunar stroke, but not large artery or cardioembolic stroke. The association may act through increased susceptibility to, or interaction with, high blood pressure. This heterogeneity of association might explain the lack of effect of lowering homocysteine in secondary prevention trials which included all strokes.