Clinical Chemistry · 1976 · 21 citations · 0 references
MedicineNeurologyToxicologyNeuropathologyNeurotoxicologyPediatric NeurologyCentral Nervous System ToxicityCerebrospinal Fluid BiomarkersCerebrospinal Fluid AnalysisCerebrospinal Fluid DiagnosticsCerebrospinal Fluid SystemConsumption CoagulopathyIsoenzyme ClassificationIsoenzyme FunctionSerum Creatine Kinase AssessmentToxic Encephalopathy
We present a case of a 11/2-year-old boy with toxic enteritis, consecutive consumption coagulopathy, and sever brain damage. During the acute phase we found high activity of the BB isoenzyme of creatine kinase in cerebrospinal fluid, but not in the serum. Isoenzyme MM could also be found in the spinal fluid (37.9% of the total activity). We conclude that analysis for creatine kinase isoenzymes in spinal fluid is of clinical importance.