Concepedia

Syndactyly in a novel <i>Fras1</i><sup><i>rdf</i></sup> mutant results from interruption of signals for interdigital apoptosis

Elizabeth A Hines, Jamie M. Verheyden, Amber J. Lashua, Sarah C. Larson, Kelsey Branchfield, Eric T. Domyan, Juan Gao, Julie F. Harvey, John Herriges, Linghan Hu,

Developmental Dynamics · 2016 · 12 citations · 38 references

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Abstract

The close correlation between limb bud epidermal blistering, decreased Msx2 expression, and reduced ICD in the Fras1(rdf) hindlimb buds suggests that epithelium detachment from the mesenchyme may create a physical gap that interrupts the transmission of BMP, among other signals, resulting in soft tissue syndactyly.

References

38

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