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Inverse Correlation Between Tumor Incidence and Tissue Histamine Levels in <italic>W/W</italic><sup><italic>v</italic></sup>, <italic>W</italic><sup>V</sup>/+, and +/+ Mice<xref ref-type="fn" rid="FN2">2</xref>
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1985
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EngineeringTumor IncidenceMast Cell DisorderImmunologyPathologyExperimental PathologyCell ProliferationCancer BiologyTumor BiologyGrowth RateMolecular PathologyMolecular DiagnosticsCancer ResearchTissue Histamine LevelsHistopathologyMast CellsBiomedical Analysis+/+ MiceCell BiologyMalignant DiseaseTumor MicroenvironmentTumoral PathologyGeneral PathologyMedicine
The influence of mast cells on tumor incidence and growth rate was studied in 2 grafted tumor models (fibrosarcoma MC-B6-1 and the Lewis lung carcinoma 3LL). Three kinds of WBB6F1 mice (a cross between WB/ReJ-W/+ and C57BL/6J-WV/+ mice) were used: W/WV (deeply mast cell depleted), WV/+ (partially mast cell depleted), and +/+ (normal mast cell number). The presumed resistance of F1 hybrids to tumor cells of parental origin was observed in 12 of 13 +/+ mice, but only in 11 of 22 WV/+ mice and in none of 39 W/WV mice. Tumor incidence and metastasis incidence were inversely correlated with tissue histamine levels and mast cell number. Growth rates of tumors were similar in W/WV and WV/+ mice, but the tumor growth rate was much slower in the only +/+ mouse in which the tumor grew. These results confirm the protective role of mast cells against tumors.