Recent Advances in Bromination of Aromatic and Heteroaromatic Compounds

Abstract

This review covers recent advances in C–H bromination of aromatic substrates. Transition-metal-catalyzed/-mediated reactions and transition-metal-free methods are discussed. 1 Introduction 2 Transition-Metal-Catalyzed Bromination 2.1 Palladium-Catalyzed Reactions 2.2 Rhodium-, Cobalt- and Ruthenium-Catalyzed Reactions 2.3 Copper-Mediated Reactions 2.4 Gold-Catalyzed Reactions 3 Transition-Metal-Free Bromination 3.1 Conventional Electrophilic Bromination 3.2 Oxidative Bromination 3.3 Bromination of Heterocyclic <i>N</i>-Oxides 4 Conclusions