Concepedia

Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

Dmitry Katayev, Jiří Václavík, Fabian Brüning, Bruno Commare, Antonio Togni

Chemical Communications · 2016 · 39 citations · 41 references

DOI

Concepts

Abstract

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

References

41

The Many Roles for Fluorine in Medicinal Chemistry

William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

, , +5

Molecular Design of Photovoltaic Materials for Polymer Solar Cells: Toward Suitable Electronic Energy Levels and Broad Absorption

Yongfang Li · Accounts of Chemical Research · 2012 · 2.7K citations

, , +17

Introduction of Fluorine and Fluorine‐Containing Functional Groups

Theresa Liang, Constanze N. Neumann, Tobias Ritter · Angewandte Chemie International Edition · 2013 · 2.5K citations · Full text

, , +9

Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

David A. Nagib, Mark E. Scott, David W. C. MacMillan · Journal of the American Chemical Society · 2009 · 973 citations · Full text

, , +15

Fluorine in health care: Organofluorine containing blockbuster drugs

David O’Hagan · Journal of Fluorine Chemistry · 2010 · 846 citations

, , +4