An Investigation of (Diacetoxyiodo)arenes as Precursors for Preparing No-Carrier-Added [¹⁸F]Fluoroarenes from Cyclotron-Produced [¹⁸F]Fluoride Ion

Abstract

Treatment of (diacetoxyiodo)arenes (1a-1u) with cyclotron-produced [(18)F]fluoride ion rapidly affords no-carrier-added [(18)F]fluoroarenes (2a-2u) in useful yields and constitutes a new method for converting substituted iodoarenes into substituted [(18)F]fluoroarenes in just two steps.