3-Component synthesis of α-substituted sulfonamides via Brønsted acid-catalyzed C(sp³)–H bond functionalization of 2-alkylazaarenes

Abstract

A Brønsted acid-catalyzed addition of 2-alkylazaarenes to in situ generated N-sulfonylimines through selective C(sp(3))-H bond functionalization has been developed. This protocol provides an atom- and step-economic approach to α-substituted sulfonamides.