Superinfection With Adenovirus of Burkitt's Lymphoma Cell Lines2

Abstract

Two Burkitt's lymphoma cell lines, Epstein Barr (EB) virus-positive (Jijoye cells), and EB virus-negative (Raji cells), were exposed to adenovirus type 5 to enhance replication of the EB virus. Average cell growth was not reduced compared with that of control populations. Adenovirus multiplied in Jijoye cells at a higher rate than in Raji cells. In the presence of fB virus antiserum, a few cells appeared fluorescent in the Raji cell line; in the JiJoye cell line, the number of EB viral antigen-producing cells increased.