Deposition of fat in the liver and carcass of the rat on diets high in fat and low in lipotropic factors

Abstract

IN continuation of previous studies of factors influencing the production of dietary fatty livers in rats, Channon & Wilkinson [1936] investigated the degree to which certain fats of widely varying chemical composition and physical properties accumulated in the livers when fed as 40 % of a diet which was low in choline (choline intake about 1*5 mg. per rat per day) and which contained alcoholand ether-extracted caseinogen 5, glucose 45, marmite 5, salt mixture 5 parts with 1 drop of cod liver oil per animal every 3 days. This work was under- taken in the first place in order to obtain information concerning the nature of the fatty acids which appeared in the liver under these different conditions and because knowledge of this kind should provide evidence as to the effect of the chemical nature of the food fat in fatty liver production. The results as far as the fatty liver problem is concerned are recorded by Channon & Wilkinson in the communication already cited.