Asian Journal of Pharmaceutical Research · 2012 · 17 citations · 0 references
PharmacyPharmaceuticsPharmacologyBioavailabilityDosage Form DesignDrug DeliveryControlled Release Oral Dosage FormsDrug Delivery SystemsDrug Release From Dosage FormsDrug Release KineticsSustained Release FormulationsTablet DesignFloating CapsulesGastrointestinal ReleaseGastroretentive Drug DeliveryGastroretentive FormulationsGastroretentive SystemsIn Vivo StudiesOral Drug Delivery FormulationsOral Drug Delivery Systems
Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. The recent developments of floating drug delivery systems (FDDS) including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems. Floating dosage form can be prepared as tablets, capsules by adding suitable ingredients as well as by adding gas generating agent. In this review various techniques used in floating dosage forms along with current & recent developments of stomach specific floating drug delivery system for gastro retention are discussed.