THE METABOLISM OF GLUTAMATE IN HOMOGENATES AND SLICES OF BRAIN CORTEX

Abstract

Glutamate is a highly active metabolite in the cerebral cortex.It can be converted into a-oxo- glutarate by transamination or dehydrogenation; it can be decarboxylated to y-aminobutyrate, and its carbon skeleton can be synthesized from glucose and intermediates of glucose metabolism (see Waelsch & Lajtha, 1961;