Tyrosinase Inhibitor Fatty Ester and a Quinoline Alkaloid from Skimmia laureola

Abstract

Aerial parts of Skimmia laureola yielded a new tyrosinase inhibitor fatty ester, (+)-skimmidiol (1), and a new alkaloid ribaliprenylene (2). The configuration at C-3’ in 1 was established by Horeau’s procedure. Compound 1 was screened for its enzyme inhibitory activity against tyrosinase (E.C.1.14.18.1), exhibiting activity with IC 50 51.25±1.10165 μ M .