The secretion of pancreatic juice in the presence of atropine or hyoscyamine in chronic fistula dogs.

Abstract

1. Doses of atropine or hyoscyamine sufficient to block the secretory endings of the vagus nerves decreased the specific gravity and total nitrogen of the pancreatic juice in unanesthetized dogs regardless of the stimulus used to promote secretion. 2. When the stimulus was soap or HCl in the intestine or intravenous secretin the volume of the secretion was also decreased by the action of these drugs. The response to secretin was affected least. 3. The volume of pancreatic juice obtained in response to peptone in the intestine was increased by atropine or hyoscyamine in seven of ten normal dogs. 4. The secretory response of the pancreas which normally follows injection of peptone into a modified Thiry loop of the duodenum or jejunum was abolished by atropine or hyoscyamine.