Concepedia

Publication | Closed Access

An adult canine model of chronic pulmonary hypertension for cardiopulmonary transplantation.

20

Citations

0

References

1997

Year

E. P. Chen, H Bittner, Frank Tull, Santanu Biswas, R D Davis, Peter Van Trigt
PubMed

Abstract

A chemically-induced canine model of CPH has been created. Significant increases in mRVP, mPAP, and pulmonary capillary wedge pressure were observed 6 weeks after MCTP injection. RV function adapts to the increased afterload in the short term without evidence of failure. A stable model of pulmonary hypertension is provided as a potential means to evaluate posttransplantation RV dysfunction in the setting of CPH.