Concepedia

Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.

Giuseppe Germanò, Martina Pigazzi, Laura del Giudice, Marta Dell’Orto, Andrea Zangrando, Paolo Paolucci, Saverio Ladogana, Giuseppe Basso

PubMed · 2006 · 19 citations · 2 references

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Abstract

An 18-month-old girl was diagnosed with pre-pre-B ALL/t(4;11) leukemia, which during the treatment and after matched bone marrow transplantation (BMT), underwent two consecutive switches from lymphoid to myeloid lineage and vice versa. The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.

References

2

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

H. Jeffrey Lawrence, Julie Anja Engelhard Christensen, Stephen S. Fong et al. · Blood · 2005 · 229 citations · Full text

, , +17

New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes

Alexander Kohlmann, Claudia Schoch, Martin Dugas et al. · Leukemia · 2005 · 93 citations

, , +16